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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Neurobiol Learn Mem. 2018 Dec 3;157:79–85. doi: 10.1016/j.nlm.2018.12.002

Figure 3. HIF-1α icKO mice display impaired performance on TUNL touch screen pattern separation task.

Figure 3.

A. Experimental timeline. Mice were treated for 5 consecutive days with tamoxifen to induce Cre-mediated recombination within nestin+ hippocampal progenitors. Forty-five days following the final tamoxifen injection, mice began habituation and training on the TUNL pattern separation task using a touchscreen paradigm. All mice were sacrificed seven days following the final day of behavioral testing. B. Cartoon depiction of computer touch screen depicting an example of lighted squares during testing for discrimination of maximally separated squares (MAX) vs discrimination of pattern in which lighted squares are closer together (FAR). C. Percent correct choices for mice tested for pattern separation with MAX vs. FAR touchscreen patterns over 5 consecutive days. Two-way ANOVA revealed significant effects of time (F(4,52)=7.587, p<0.0001), genotype (F(1,13)=13.52, p=0.0028) with no significant interaction for performance on the FAR separation test. There was no significant effects of genotype in performance of MAX separation TUNL test.