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Linagliptin activated the NRF2 antioxidant pathway. The expression levels of the KEAP1, nuclear NRF2, HO-1 and NQO1 were determined by Western blot (A). The binding capacity of NRF2 to ARE was assessed by EMSA (B).The data were presented as mean ± SD (n=6 for each group. *P<0.05, **P<0.01, compared with sham group; #P<0.05, ## P<0.01, ### P<0.001 compared with injury group; one-way ANOVA followed by the Bonferroni test).
