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. 2019 Feb 19;10:22. doi: 10.3389/fgene.2019.00022

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Copyright © 2019 Liu, Yang, Jiang, Xu, Tang, Lobo, Zhang, Liu, Yu and Xin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CDK1 was involved in miR-378a-5p-mediated cellular effects. (A,B) Low expression of CDK1 promoted VSMC migration and significantly promoted the migratory effects of miR-378a-5p on VSMCs, as determined by wound closure and its quantification analysis, data are presented as mean ± SEM. ^∗p < 0.05 and ^∗∗p < 0.01. (C,D) The same effects was also determined by transwell assay (original magnificaton: × 200) and its quantification analysis, data are presented as mean ± SEM. ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001.