Table 1.

ER stress decreased the ADP-stimulated respiration in cardiac mitochondria using pyruvate + malate as substrates.

	WT (n = 12)	WT + THAP (n = 7)	KO (n = 10)	KO + THAP (n = 6)
COMPLEX I SUBSTRATES: PYRUVATE + MALATE
State 3	370 ± 10	284 ± 21*	350 ± 10	348 ± 30
State 4	80 ± 5	102 ± 6*	93 ± 5	111 ± 10
RCR	4.4 ± 0.1	2.8 ± 0.2*	3.8 ± 0.2	3.2 ± 0.1
COMPLEX II SUBSTRATES: SUCCINATE
State 3	579 ± 21	587 ± 19	598 ± 21	610 ± 24
State 4	173 ± 3	179 ± 8	193 ± 10	185 ± 11
RCR	3.3 ± 0.1	3.3 ± 0.1	3.2 ± 0.2	3.3 ± 0.1

Mean ± SEM:

^*p < 0.05 vs. WT.