Table 3.
Comparison of mechanical parameters between myofibrils from ARVMs treated with PE for 48 h.
| Vehicle (N, n) | PE (N, n) | P | |
|---|---|---|---|
| Sarcomere length (μm) | 2.21 ± 0.1 (6, 19) | 2.21 ± 0.1 (6, 22) | ns |
| Resting tension (mN /mm2) | 7.6 ± 2.8 (6, 18) | 6.7 ± 2.5 (6, 17) | ns |
| Maximal Tension (mN /mm2) | 135.8 ± 47.6 (6, 17) | 118.8 ± 38.6 (6, 17) | ns |
| KACT (s−1) | 4.05 ± 0.98 (6, 19) | 3.95 ± 0.94 (6, 19) | ns |
| KTR (s−1) | 4.90 ± 0.95 (6, 19) | 4.37 ± 1.02 (6, 19) | P = 0.059 |
| Linear Relaxation Duration (ms) | 34.2 ± 8.5 (6, 15) | 43.8 ± 17.1 (6, 15) | ns |
| Linear Relaxation Rate (s−1) | 1.27 ± 0.91 (6, 6) | 1.35 ± 0.65 (6, 8) | ns |
| Exponential Relaxation Rate (s−1) | 9.04 ± 3.3 (6, 15) | 10.0 ± 5.1 (6, 19) | ns |
Myofibrils are fully calcium activated (pCa 4.5) and fully relaxed (pCa 9) by fast solution switching. Data presented with mean ± SEM. (N,n), (N# of rats, n # of myofibrils).