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Scheme of the presence of NPF/NPY neuropeptides and receptors in distinct phyla of the metazoan evolutionary tree. The NPF(Y) C-terminal sequence motif is indicated. “✓” and “✗,” respectively represent the presence or absence of the peptide/receptor in the corresponding phylum. Evidence for the presence of both NPY/F peptides and receptors in cephalochordates and hemichordates can be found in Elphick et al. (40).
