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Loss of JAK1 decreases the cytotoxicity of T-cells. OT-I T-cells and indicated B16/OVA cells and their derivatives were co-cultured (E: T = 3:1 or 9:1) for 48 h, and the production of TNF-α (A,B), granzyme B (C,D), and perforin (E,F) were analyzed by intracellular flow cytometry. Data are presented as mean ± SEM. **P < 0.01 vs. blank group; ##P < 0.01 vs. B16/OVA + OT-I T-cell group.
