Table 5.
Multivariable Cox regression model predicting overall mortality, stratified by cancer stage.
| Variable | Category | HR (95%CI) | P value |
|---|---|---|---|
| EARLY STAGE (1–3) | |||
| Age2before | 51–60 years old vs. < 50 up to 5 years FU | 1.04 (0.89, 1.21) | 0.6433 |
| Age3before | 61–70 years old vs. < 50 up to 5 years FU | 1.39 (1.21, 1.59) | < 0.001 |
| Age4before | 71–80 years old vs. < 50 up to 5 years FU | 2.10 (1.84, 2.39) | < 0.001 |
| Age5before | >80 years old vs. < 50 up to 5 years FU | 4.08 (3.56, 4.68) | < 0.001 |
| Age2after | 51–60 years old vs. < 50 after 5 years FU | 2.09 (1.77, 2.46) | < 0.001 |
| Age3after | 61–70 years old vs. < 50 after 5 years FU | 4.50 (3.86, 5.25) | < 0.001 |
| Age4after | 71–80 years old vs. < 50 after 5 years FU | 10.36 (8.87, 12.11) | < 0.001 |
| Age5after | >80 years old vs. < 50 after 5 years FU | 21.88 (18.43, 25.97) | < 0.001 |
| Gender | Male | 1.29 (1.23, 1.34) | < 0.001 |
| Year diagnosis category | 1980–1999 | 1.23 (1.07, 1.41) | 0.003 |
| Year diagnosis category | > = 2000 | 1.01 (0.87, 1.16) | 0.9118 |
| Cancer location | Left vs. Right | 0.99 (0.93, 1.04) | 0.6443 |
| Cancer location | Rectum vs. Right | 1.12 (1.06, 1.18) | < 0.001 |
| Cancer stage | Stage1 vs. stage 0 | 1.14 (1.02, 1.28) | 0.0258 |
| Cancer stage | Stage2 vs. stage 0 | 1.40 (1.25, 1.58) | < 0.001 |
| Cancer stage | Stage3 vs. stage 0 | 1.83 (1.63, 2.06) | < 0.001 |
| LATE STAGE (4) | |||
| Age2before | 51–60 years old vs. < 50 up to 5 years FU | 1.09 (0.95, 1.24) | 0.2064 |
| Age3before | 61–70 years old vs. < 50 up to 5 years FU | 1.25 (1.11, 1.41) | < 0.001 |
| Age4before | 71–80 years old vs. < 50 up to 5 years FU | 1.68 (1.48, 1.91) | < 0.001 |
| Age5before | >80 years old vs. < 50 up to 5 years FU | 2.59 (2.23, 3.02) | < 0.001 |
| Age2after | 51–60 years old vs. < 50 after 5 years FU | 1.30 (0.85, 1.99) | 0.2201 |
| Age3after | 61–70 years old vs. < 50 after 5 years FU | 2.32 (1.54, 3.48) | < 0.001 |
| Age4after | 71–80 years old vs. < 50 after 5 years FU | 2.68 (1.69, 4.24) | < 0.001 |
| Age5after | >80 years old vs. < 50 after 5 years FU | 7.37 (2.23, 24.34) | 0.0011 |
| Gender | Male | 1.05 (0.97, 1.13) | 0.2266 |
| Year diagnosis category | 1980–2000 | 1.83 (1.53, 2.20) | < 0.001 |
| Year diagnosis category | > = 2000 | 1.23 (1.02, 1.49) | 0.0264 |
| Cancer location | Left vs. Right | 0.73 (0.67, 0.80) | < 0.001 |
| Cancer location | Rectum vs. Right | 0.76 (0.69, 0.83) | < 0.001 |
Proportional hazard assumption was not met for age category, so age was included in the model as time-dependent coefficients.