Table 7.
Characteristics of right and left colorectal cancer.
| Characteristics | References |
|---|---|
| • Older age at diagnosis for right-sided colon cancer | (3, 5, 7, 9, 16) |
| • Patients diagnosed with right-sided colon cancer more likely to be female • More poorly differentiated tumors in right-sided colon cancer |
|
| • Comorbidities more common in patients with right-sided colon cancer | |
| • Higher stage at diagnosis for right-sided colon cancer | (7, 17) |
| • Number of lymph nodes examined is higher in right-sided colon cancer | |
| • Higher CA19–9 serum level in right-sided colon cancer | |
| • African Americans more likely to develop right-sided colon cancer | |
| • Left-sided colon cancer more commonly seen in patients with familial adenomatous polyposis, whereas right-sided colon cancer is associated more with MSI-High status | (16) |
| • Left-sided colon cancer are more often aneuploid and right-sided colon cancer more diploid | |
| • Right-sided colon cancer associated with higher C-reactive protein, which is associated with higher risk of morbidity | (7, 10, 11) |
| • CDX2-negative metastatic CRC more likely right-sided, and is also associated with worse overall survival |