Table 4.

Results from conditional logistic regressions models showing associations between red meat density (non-processed and processed) and (a) risk of FCD including only participants with plausible energy intakes (>500 to < 5,000 kcal/day), (b) risk of FCD in case participants who completed the study interview within 90 days from the date of MRI scan, (c) risk of FDE.

		Unadjusted		Adjusteda
	n (cases, controls)	OR (95% CI)	P	AOR (95% CI)	P
NON-PROCESSED RED MEAT DENSITY (g/1,000 kcal/day, per SD)
(a) risk of FCD including only participants with plausible energy intakes (>500– < 5,000 kcal/day)
Total	676 (430, 246)	0.81 (0.69, 0.96)	0.02	0.82 (0.69, 0.98)	0.03
Males	161 (101, 60)	1.10 (0.80, 1.50)	0.57	1.14 (0.77, 1.70)	0.51
Females	515 (329, 186)	0.73 (0.59, 0.89)	0.002	0.74 (0.60, 0.92)	0.01
(b) risk of FCD in case participants who completed the study interview within 90 days from the date of MRI scan
Total	316 (115, 201)	0.86 (0.68, 1.08)	0.20	0.87 (0.67, 1.11)	0.26
Males	93 (34, 59)	1.28 (0.82, 2.01)	0.28	1.69 (0.90, 3.16)	0.10
Females	223 (81, 142)	0.71 (0.53, 0.96)	0.03	0.71 (0.52, 0.97)	0.03
(c) Risk of FDE
Total	519 (191, 328)	0.82 (0.68, 0.99)	0.04	0.80 (0.65, 0.98)	0.03
Males	129 (48, 81)	1.07 (0.75, 1.51)	0.72	1.07 (0.69, 1.66)	0.76
Females	390 (143, 247)	0.73 (0.58, 0.92)	0.01	0.71 (0.55, 0.92)	0.01
PROCESSED RED MEAT DENSITY (g/1,000 kcal/day, per SD)
(a) risk of FCD including only participants with plausible energy intakes (>500– < 5,000 kcal/day)
Total	670 (426, 244)	1.00 (0.85, 1.18)	0.98	1.04 (0.88, 1.23)	0.64
Males	159 (99, 60)	0.93 (0.68, 1.27)	0.64	0.92 (0.64, 1.32)	0.65
Females	511 (327, 184)	1.03 (0.86, 1.24)	0.75	1.08 (0.89, 1.31)	0.45
(b) Risk of FCD in case participants who completed the study interview within 90 days from the date of MRI scan
Total	313 (114, 199)	1.00 (0.80, 1.25)	0.99	1.05 (0.82, 1.33)	0.70
Males	92 (34, 58)	1.00 (0.70, 1.43)	0.996	1.02 (0.64, 1.62)	0.93
Females	221 (80, 141)	1.00 (0.75, 1.32)	0.99	1.03 (0.76, 1.40)	0.83
(c) Risk of FDE
Total	518 (190, 328)	0.99 (0.83, 1.18)	0.89	1.02 (0.85, 1.23)	0.81
Males	128 (48, 80)	0.90 (0.66, 1.24)	0.53	0.94 (0.65, 1.35)	0.75
Females	390 (142, 248)	1.03 (0.83, 1.27)	0.80	1.06 (0.85, 1.33)	0.58

FCD, first clinical diagnosis of central nervous system demyelination; MRI, magnetic resonance imaging; FDE, incident classic first demyelinating event.

^aAdjusted for history of infectious mononucleosis, serum 25-hydroxyvitamin D concentrations, total years of smoking, body mass index, race, education, and dietary misreporting.