Table 1.
Susceptibility of M. tuberculosis efflux pump Rv1258c point mutation mutants to different TB drugs.
| Drugs | MIC breakpoints |
Drug susceptibility results# |
|
|---|---|---|---|
| H37Ra (μg/ml) | Rv1258c V219A | Rv1258c S292L | |
| Isoniazid | 0.05 | R (MIC 0.125 μg/ml) | R (MIC 32 μg/ml) |
| Pyrazinamide | 50 | R (MIC 100 μg/ml) | R (MIC 800 μg/ml) |
| Streptomycin | 0.5 | S | R (MIC 4.0 μg/ml) |
| Rifampin | 1.0 | S | S |
| Ethambutol | 5.0 | S | S |
| Amikacin | 1.0 | S | S |
| Cycloserine | 10 | S | S |
| p-aminosalicylic acid (PAS) | 0.20 | S | S |
| Clofazimine | 0.20 | S | S |
| Tetracycline | 8.0 | S | S |
| Linezolid | 0.5 | S | S |
| Clarithromycin | 2.0 | S | S |
# S indicates “susceptible”; R indicates “resistant”.