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. 2019 Feb 19;10:232. doi: 10.3389/fimmu.2019.00232

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Copyright © 2019 Horai and Caspi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fundus images of R161H mice under germ-free (GF) or specific pathogen-free (SPF) conditions. Fundus images were taken by Micron II. WT mice (SPF or GF) do not develop spontaneous uveitis and show normal fundus. SPF R161H mice develop moderate to severe uveitis and inflammation peaks between 2–3 months of age. Diffuse lesions and inflammation along the vessels and away from the vessels are present. GF R161H mice develop milder uveitis with focal inflammation/lesions. Photos were taken at 11 weeks old except for GF WT mice at 7 weeks old.