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Microbiota-dependent activation of retina-specific autoreactive T cells triggers uveitis. A high frequency of retina-specific autoreactive T cells is present in the periphery including gut LP of R161H mice (1). Gut microbiota-derived products, which may mimic Ag to these T cells, are presented by antigen presenting cells (2). Retina-specific T cells become activated, migrate to the eye (3), and cross the blood retinal barrier to cause inflammation in the retina (4).
