Table 1.

Comparison of the effects of microbiota on disease and related immune responses in the spontaneous vs. induced uveitis models in B10.RIII mice.

Effect	Spontaneous uveitis in R161H mice (5, 6)	EAU model induced by immunization with IRBP/CFA (7, 9)
Prevention of disease by antibiotic treatment	Yes	Yes
Duration of protective effect	Prolonged	Temporary*
Treg induction during treatment	No	Yes (antibiotic driven)
Single antibiotics effective?	No—all 4 antibiotics needed	Yes (metronidazole or vancomycin)
Differences in gut microbiota between healthy and uveitis	None detected*	Yes

^*Supported by our unpublished data.