Table 3.
Self-antigens and microbial mimicry in autoimmune diseases.
| Self-antigen | Tissue where self-antigen is expressed | Disease | Species | Microbe or mimicry | Reference |
|---|---|---|---|---|---|
| IGRP | Islet | T1D | Mouse | Leptotrichia goodfellowii (Fusobacteria) | (17) |
| Collagen | Periodontal tissue | Periodontitis | Human | Prevotella sp. hypothetical protein | (18) |
| GNS | Synovial tissue | RA | Human | Prevotella and Prabacteroides | (19) |
| FLNA | Synovial tissue | RA | Human | Prevotella and Butyricimonas | (19) |
IGRP, islet-specific glucose-6-phosphatase catalytic subunit-related protein; GNS, N-acetylglucosamine-6-sulfatase; FLNA, filamin A; T1D, type 1 diabetes; RA, rheumatoid arthritis.