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. 2019 Feb 19;9:28. doi: 10.3389/fcimb.2019.00028

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Copyright © 2019 Nearing, Connors, Whitehouse, Van Limbergen, Macdonald, Kulkarni and Langille.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phylogenetic Diversity based on 16S rRNA gene sequencing is significantly different between samples from patients that face infectious complications (IC) within the first 6 months of therapy and those that do not (NIC). Differences in alpha diversity between samples from IC and NIC patients that were sequences by 16S rRNA gene sequencing at a read depth of 1481 (37 of 44 total samples). Significance was determined using a Wilcoxon rank sum test at an alpha value of 0.05 (represented by ^*). Each panel represents a different measure of alpha diversity; shannon diversity (A), number of amplicon sequence variants (B), evenness (C), and Faith's phylogenetic diversity (D). Points are colored by individual (Supplementary Figure 1).