FIGURE 4.

Impaired cytokine secretion in whole lung homogenates of PGLYRP2-KO mice. Mice were infected with S. pneumoniae (A66, 10⁵ CFU) for 48 h. (A) KC, (B) IL-6, (C) IFN-γ, and (D) TNF-α were measured by multiplex ELISA. Sample size: WT and PGLYRP2-KO PBS: n = 6 each, WT infected: n = 8, PGLYRP2-KO infected: n = 7. Data are represented by the means + SEMs. Thresholds for nondetection were set to the half of the lower limit of detection for statistical purposes. Statistics: ordinary one-way ANOVA with Holm-Sidak’s correction for multiple comparisons on logarithmic data. ^∗p ≤ 0.05, ^∗∗p ≤ 0.01, ^∗∗∗p ≤ 0.001, ^∗∗∗∗p ≤ 0.0001, ns: not significant.