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. 2019 Feb 19;10:98. doi: 10.3389/fgene.2019.00098

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Copyright © 2019 Huang, Lai, Du, Xu, Ruan and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The taxonomic tree and function of main fecal bacterial clades in MDD and BD. The taxonomic tree shows the common and different features of gut microbiota composition between MDD and BD patients, as well as the physiological functions of the specific bacteria. Decreased in SCFAs-producing genera and increased in pro-inflammatory genera was reported both in patients with BD and MDD. # There were four studies showing lower Bacteroidetes levels in MDD patients, with one study showing higher abundance of Bacteroidetes in MDD patients. Similarly, the abundance of Lachnospiraceae was decreased in two studies in MDD patients, but another study showed Lachnospiraceae was increased in MDD patients. SCFAs, short-chain fatty acids; IBS, irritable bowel syndrome; 5-HT, 5-hydroxytryptamine.