Table 1.
Study cohorts
| Variable | CAL∗ |
DIAN-TU |
ADRC crossover |
ADRC longitudinal |
|||
|---|---|---|---|---|---|---|---|
| Noncarrier | Carrier | Noncarrier | Carrier | PiB | Florbetapir (AV45) | ||
| N | 15 | 22 | 50 (29 YC, 21 OC) | 132 | 103 | 54 | 26 |
| Age (SD) years | 39.3 (4.6) | 54.5 (6.3) | 43.3 (8.9) | 44.6 (10.1) | 67.4 (8.9) | 71.4 (7.0) | 72.1 (6.8) |
| Male (%) | 7 (46.7) | 14 (63.6) | 26 (52.0) | 62 (47.0) | 44 (42.7) | 23 (42.6) | 13 (50.0) |
| APOE ε4+ (%) | 4 (26.7) | 9 (40.9) | 16 (32.0) | 38 (28.8) | 36 (35.0) | 35 (64.8) | 15 (57.7) |
| CDR > 0 (%) | 0 (0.0) | 16 (72.7) | 3 (6.0) | 20 (15.2) | 5 (4.9) | 9 (16.7) | 4 (18.2) |
| Interval between scans (years) | - | - | - | 2.2† | 3.3† | ||
Abbreviations: ADRC, Alzheimer's Disease Research Center; APOE, apolipoprotein E; CDR, Clinical Dementia Rating; DIAN-TU, Dominantly Inherited Alzheimer's Network Trial Unit; OC, old controls; PiB, Pittsburgh compound B; SD, standard deviation; YC, young controls (<45 yrs old).
∗
CAL (calibration data set) is a subset of DIAN-TU and is used for establishing the florbetapir Centiloid conversions.
†
Significantly different (P < .0001 based on the Welch two-sample t-test).