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. 2019 Feb 19;10:203. doi: 10.3389/fimmu.2019.00203

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Copyright © 2019 Schinnerling, Rosas, Soto, Thomas and Aguillón.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transgenic mouse models of rheumatoid arthritis. Transgenic (Tg) mouse models of rheumatoid arthritis (RA) reported in the literature include mice expressing (i) RA-susceptible human leukocyte antigen (HLA) class II molecules, such as DRB1*0101 (DR1) or DRB1*0401 (DR4); (ii) human RA-associated autoantigens, such as type II collagen (CII), either complete or as mutated mouse collagen (MMC) containing the immunodominant epitope, and human cartilage glycoprotein-39 (HCgp-39); (iii) an autoantigen-specific T cell receptor (TCR) alone; or (iv) together with RA-susceptible HLA-DR molecules. Advantages are depicted in green color, limitations in red.