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Overview of study design. Spiking and nonspiking tissue from N = 6 patients was obtained and assessed by RNA sequencing. Differentially expressed genes (spiking vs. nonspiking) were compared to gene expression profiles in the CMAP database, to identify compounds that reverse the differential expression signature, suggesting a potentially therapeutic activity. Four of these compounds were tested further for their antiseizure properties in a zebrafish model of seizures.
