Table 1.
Summary of patient clinical data
| Patient | Age of seizure onset | Age at surgery | Seizure type | # of AED trials | AEDs at time of biopsy | Final pathologic diagnosis | Outcome |
|---|---|---|---|---|---|---|---|
| 302 | 1 y.o. | 46 y.o. | Complex partial | 12 | 4 | Anterior Hippocampus: no diagnostic abnormality; Posterior Hippocampus: hippocampal sclerosis; Amygdala: rare abnormally clustered neurons and mild patchy gliosis | Engel IIB |
| 316 | 15 y.o. | 31 y.o. | Complex partial | 6 | 2 | Right temporal cortex: mesial temporal sclerosis, changes suggestive of focal cortical dysplasia; Anterior Hippocampus: mesial temporal sclerosis; Posterior Hippocampus: mesial temporal sclerosis; Amygdala: focal hemorrhage and granulation tissue consistent with prior electrode placement | Engel ID |
| 334 | 7 y.o. | 40 y.o. | Complex partial | 17 | 3 | Lateral Temporal Cortex: gliosis and changes related to recent dural grid monitoring; Temporal Pole: gliosis, predominantly involving the white matter; Posterior Lateral Temporal Cortex: gliosis and changes related to recent dural grid monitoring; Anterior Parahippocampal Gyrus: focal cortical dysplasia ILAE type Ib; Posterior Parahippocampal Gyrus: pigmented ganglioglioma WHO grade I, see comment, focal cortical dysplasia ILAE type IIa,; Amygdala: focal cortical dysplasia ILAE type Ib; Anterior Hippocampus: focally involved by ganglioglioma, patchy gliosis and changes related to recent dural grid monitoring; Posterior Hippocampus: focally involved by ganglioglioma, patchy gliosis and changes related to recent dural grid monitoring; comment – the pigmented ganglioglioma is “arising in the background of cortical dysplasia.” | Engel IA |
| 282 | 8 y.o. | 41 y.o. | Complex partial | 11 | 3 | Left Frontal Cortex: prominent gliosis, mostly involving white matter; Temporal Cortex: mild gliosis predominately involving the white matter; Lateral Temporal Cortex: mild gliosis involving white matter and focal areas of cortex; Amygdala: prominent gliosis; Hippocampus: gliosis predominately involving white matter | Engel IIC |
| 284 | 7 y.o. | 41 y.o. | Complex partial | 4 | 2 | Temporal Cortex: focal cortical dysplasia, gliosis; Amygdala: focal cortical dysplasia, gliosis; Hippocampus: focal cortical dysplasia, gliosis | Engel IA |
| 292 | 6 mo. | 50 y.o. | Complex partial | 8 | 2 | Amygdala: patchy marked superficial and deep cortical and white matter gliosis, with neuronal clustering; Frontal Cortex: rare superficial cortical and white matter neurons, with mild patchy gliosis of the superficial cortex and white matter; Hippocampus: rare white matter neurons and mild patchy gliosis of the cortex and white matter | Engel IB |
Table listing the relevant clinical information of patients from whom tissue samples were procured. Information includes age of onset of first seizure, age at which the biopsy was performed, classification of seizure type, the number of AED trials, the number of AEDs the patient was on at the time of surgery, a description of the pathology of biopsied areas, and the outcome following surgery as described using the Engel Surgical Outcome Score. (y.o. = years old) (mo. = months).