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. 2019 Jan 29;12:195–203. doi: 10.1016/j.omto.2019.01.004

Figure 4.

Figure 4

Cathelicidin-Mediated Inhibition of Colon Cancer Cell Migration Was P2RX7 Dependent

(A) SW620 cells were transfected with control lentivirus or TUBB3-overexpressing lentivirus, followed by exposure to LL-37. Cell migration of SW620 cells. (B) SW620 cells were transiently transfected with control small interfering RNA (siRNA) or P2RX7 siRNA (80 pmol/mL), followed by exposure to LL-37. TUBB3 mRNA expression. (C) CAMP, (D) FPRL1, and (E) P2RX7 mRNA expression in human colon cancer PCR array plate. (F) Cell migration of SW620 cells. SW620 cells were treated with DMSO, KN62, and WRW4 for 30 min, followed by LL-37 for 7 h. Results were pooled from three independent experiments.