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. 2019 Jan 29;12:195–203. doi: 10.1016/j.omto.2019.01.004

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© 2019 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Cathelicidin Inhibited TUBB3 mRNA Expression in Metastasized Tumors via P2RX7

(A and B) Human keratin 20 mRNA expression (human colon cancer cell marker) in (A) lungs and (B) liver of nude mice was significantly reduced by CAMP-HA-AAV. Intraperitoneal KN62 treatment increased the presence of cytokeratin 18 protein and keratin 20 mRNA expression in the CAMP-HA-AAV-treated nude mice. (C and D) Human TUBB3 mRNA expression in (C) lungs and (D) liver of nude mice was significantly reduced by CAMP-HA-AAV. Intraperitoneal KN62 treatment increased the presence of human TUBB3 mRNA expression in the CAMP-HA-AAV-treated nude mice. (E) Diameters of subcutaneous tumors. Intravenous CAMP-HA-AAV significantly reduced subcutaneous tumor diameters in nude mice that were partially reversed by KN62 treatment.