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. 2019 Feb 5;12:235–245. doi: 10.1016/j.omto.2019.01.007

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Radioactive Iodine Efflux in BCPAP Cells, K1 Cells, and BHP 2-7 Cells

Cells were treated with 0.05 μM panobinostat and 0.1 μM dabrafenib/2.5 μM selumetinib alone or in combination. Panobinostat prolonged the retention time of radioactive iodine in all the cells. MAPKi (dabrafenib or selumetinib) had no effect in all the cells. Panobinostat combined with MAPKi (dabrafenib or selumetinib) did not further prolong retention time compared with panobinostat alone in all the cells. Data are expressed as mean ± SD. Con, DMSO control; Pa, panobinostat; Da, dabrafenib; Se, selumetinib.