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. 2019 Feb 19;12:31. doi: 10.3389/fnmol.2019.00031

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Copyright © 2019 Bielefeld, Schouten, Meijer, Breuk, Geijtenbeek, Karayel, Tiaglik, Vuuregge, Willems, Witkamp, Lucassen, Encinas and Fitzsimons.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of non-convulsive seizures on NSC identity. Example confocal images of (A) Type A NSCs (B) Type B NSCs (C) reactive NSCs, as assessed by marker expression and morphology. (D) Upon induction of ncSZ a significant loss of Type A NSCs was found. (E) At the same time, the relative proportion of Type B NSCs in the NSC pool also decreases upon induction of ncSZ. (F) Simultaneously, a significant increase in the number of rNSCs occurs, an effect that becomes even more visible when comparing the rNSC/Type A NSC ratio (G). ^∗P < 0.05.