Table 4.
Most significantly enriched canonical signaling pathways identified in liver samples of feed efficiency (FE)-divergent pigs.
| Canonical pathways | -log(p-value) | Z-score | Gene |
|---|---|---|---|
| Role of NFAT in regulation of immune response | 4.07 | 2.14£ | AKAP5, AKT3,BLNK, FRS2, GAB1, GNA11, GNAZ, GNG2, GSK3A, ITPR1, ITPR3, MEF2A, MEF2C, MS4A2, NFKBIB, ORAI1,PLCB1, SOS1, SOS2 |
| HGF signaling | 3.36 | 2.33£ | AKT3, CCND1, ELF1, ELF2, ELF3, ETS1, FRS2,GAB1, MAP3K1, MAPK9, MET, SOS1, SOS2 |
| Aldosterone signaling in epithelial cells | 3.21 | 2.12£ | DNAJB4, DNAJB12, DNAJC6, DNAJC11, DNAJC13, DNAJC16, DNAJC17, DNAJC22, FRS2, GAB1, ITPR1, ITPR3, PIKFYVE, PLCB1, SOS1,SOS2 |
| Gap junction signaling | 3.10 | NA | AKT3, CAV1, FRS2, GAB1, GUCY1B3,ITPR1, ITPR3, NPR1, PLCB1, PRKG1, SOS1, SOS2, TUBA1B, TUBB4B, TUBB, TUBG1 |
| Cell cycle regulation by BTG family proteins | 2.73 | NA | CCND1, E2F1, E2F4, PPM1J, PRMT1, PPP2R5A |
| B cell receptor signaling | 2.71 | 2.00 | AKT3, BLNK, CARD10, ETS1, FRS2,GAB1, GSK3A, MAP2K6, MEF2C, MAP3K1, MAPK9, NFKBIB, PAG1, PTEN, SOS1, SOS2 |
| tRNA charging | 2.48 | NA | AARS, EARS2, FARSA, HARS, MARS, YARS |
| ILK signaling | 2.46 | 0.00 | ACTN1, AKT3, BMP2, CCND1, FRS2, GAB1, GSK3A, KRT18, MAPK9, MAP2K6, MYH9, PPP1R14B, PPP2R5A, PTEN, PPM1J, RICTOR |
| 14-3-3-mediated signaling | 2.39 | 2.12£ | AKT3, FRS2, GAB1, GSK3A, MAPK9, PLCB1, STK11, TUBA1B, TUBB4B, TUBG1, TUBB, YWHAH |
| EGF signaling | 2.38 | 2.12£ | AKT3, FRS2, GAB1, ITPR1, ITPR3, MAP3K1, SOS1, SOS2 |
£Significantly activated (z-score > 2) pathways in high-FE pigs; up-regulated genes in high-FE pigs are highlighted in bold and down-regulated genes in normal typeface; NA, no activity pattern available.