Table 7. Effect of cyclodienes and other agents on [3H]α-dihydropicrotoxinin binding.
| Agentsb) | %Inhibition of [3H]α-DHPTX specific binding | Agentsb) | %Inhibition of [3H]α-DHPTX specific binding |
|---|---|---|---|
| Dihydropicrotoxinin | 100 | α-BHC(III) | 21.4±18.5 |
| Aldrin | 36.6±0.6 | β-BHC(II) | 15.3±15.4 |
| Dieldrin(XX) | 58.5±2.3 | γ-BHC(I) | 91.5±20.0 |
| Photodieldrin | 79.0±4.3 | δ-BHC(VI) | 55.0±16.0 |
| Heptachlor | 36.6±18.6 | ||
| Heptachlorepoxide | 57.3±31.3 | Allethrin | 13.2±6.7 |
| Isodrin | 35.6±3.8 | Cypermethrin | 7.7±3.1 |
| Endrin | 62.3±12.4 | Decamethrin | −0.1±1.0 |
| γ-Chlordane | 56.2±2.0 | Fenvarelate | −0.4±5.8 |
| Oxychlordane | 77.8±6.2 | ||
| Hexchlorocyclo-pentadiene | 0.3±2.2 | Tetramethylene-disulfotetramine (TETS) | 27.1±13.0 |
| Mirex | 14.7±15.7 | t-Butyl bicyclic phosphate | 46.6±2.9 |
| Kepone | 135.5±18.4 | Pentobarbital | 21.1±8.1 |
| Toxaphene | 72.3±28.1 | Benzodiazepam | 45.1±10.8 |
| DDT | 5.4±3.6 | SQ-65396 | 21.5±5.7 |
| Parathion | 4.1±26.3 | SQ-20009 | −8.3±4.2 |
a) [3H]α-dihydropicrotoxinin, 11.1 nM; five American cockroach heads were used for one experiment, which involved three determinations. b) Dihydropicrotoxinin, 100 µM; others, 10 µM. c)Data are expressed as means±S.E. of two or three experiments, each experiment involving three determinations.