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. 2019 Jan 15;6(2):355–363. doi: 10.1002/acn3.711

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© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Dot plots showing CD4+ T cells (A and B) and B cells (C and D) at basal state (A and C) and after 6 months of treatment (B and D). Plots are gated on CD4 T cells (A and B) and B cells (C and D). Naïve (N), central memory (CM), effector memory (EM) and terminally differentiated cells (TD) were studied according to their differential membrane expression of CD197 (CCR7) and CD45RO. Plasmablasts (PB) were studied according to their differential membrane expression of CD27 and CD38. Percentages showed in the plots are referred to total peripheral blood mononuclear cells.