Table 1.

Study characteristics of 11 studies included in meta-analysis.

Investigator	Location	Type of study	Study of design	Study population	Mean follow-up	Endpoint	Quality score
Gasparini et al., 2002	Italy	SC	PS	Patients with BrS underwent a PES protocol	20 ± 12 months	PES protocol completion/induction of sustained/reproducible nonsustained fast ventricular arrhythmia	15
Juang et al., 2003	Taiwan	MC	RS	Patients with the diagnosis of the BrS	29 ± 17 months	Seizure/syncope/sudden cardiac death	14
Mok et al., 2004	Hong Kong	MC	PS	Patients with type 1 Brugada ECGs	25.8 ± 10.9monthes	Syncope/syncopal ventricular arrhythmia/sudden death/appropriate ICD shock	20
Liang et al., 2006	China	SC	PS	Patients with Brugada ECGs or suspected Brs	NA	Syncope/VT	13
Yuan et al., 2008	China	SC	PS	patients with Brugada ECGs	NA	Syncope/VT	8
Priori et al., 2012	Italy	MC	PS	Patients with type 1 ECGs, without history of cardiac arrest	36 ± 8 months	The occurrence of VF or appropriate ICD interventions	16
Sacher et al., 2013	France	SC	RS	Patients with type 1 Brugada ECGs withimplantable cardioverter-defibrillator	77 ± 42 months	Aborted sudden cardiac arrest/syncope	16
Tokioka et al., 2014	Japan	SC	RS	Patients with a Brugada-type ECG	45.1 ± 44.3 months	VF/SCD	16
Andorin et al., 2016	Europe	MC	RS	Patients with Brugada ECG under 19 years of age	54 months	Sudden death/documented VT or VF/appropriate ICD shock	15
Calò et al., 2016	Italy	MC	PS	Patients with spontaneous type 1 BrS ECG phenotype	48 ± 38.6 months	VF/SCD	16
Yamagata et al., 2017	Japan	MC	RS	Patients with type 1 Brugada ECG pattern	72 months	Documented atrial fibrillation/appropriate ICD interventions	16

BrS, Brugada syndrome; ECG, electrocardiogram; ICD, implantable cardioverter defibrillator; PES, Programmed Electrical Stimulation; MC, multicenter study; NA, not available; n, number; PS, prospective study; RS, retrospective study; SC, single center study; SCD, sudden cardiac death; VF, ventricular fibrillation; VT, ventricular tachycardia.