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. 2019 Feb 25;9:2695. doi: 10.1038/s41598-019-39633-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

AS-SNPs identification in LCLs. 17293 unique AS-SNPs were identified running our pipeline on ChIP-seq data in 7 individual lymphoblastoid cell lines or across the cell lines (7LCLs). The collection of AS-SNPs was intersected with GWAS SNPs associated to B cell related traits and with SNPs in LD with them yielding a subset of 237 AS-SNPs associated to B cell related traits. The same approach was applied using eQTL SNPs defined in B cells and SNPs in LD with them yielding a subset of 714 AS-SNPs associated to gene expression in B cells. 58 AS-SNPs were associated to both gene expression and B cell related traits. These subsets of AS-SNPs showing evidences of biological relevance were further intersected with HiC (contact and loop domains) and HiCap data, and overlapped to TFBS predicted using PMMs.