Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 25;9:2695. doi: 10.1038/s41598-019-39633-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Multi-layered evidences for a candidate functional AS-SNP in LD with an eQTL SNP. AS-SNP rs724016 is in LD with an eQTL SNP (rs1344672) associated to the expression of ZBTB38. The SNPs are located in a genomic region with a multi loop TAD architecture defined by HiC data (purple interactions) that narrows the possible target genes to two candidates: ZBTB38 and RASA2. HiCap data (green interaction) show that the probe harboring rs724016 interacts with the promoter of ZBTB38 confirming the association observed in the eQTL study. The distal probe region (~5 kb) is highlighted in gray. Histone modifications tracks for H3K4me1, H3K4me3 and H3K27ac were retrieved from the ENCODE project for the B cell line GM12878 (scaled using vertical viewing range settings) as well as the DNaseI hypersensitive clusters (DHS). The PMM tracks show the networks of intra-motif dependencies at each position using PMMs with defined parameters. The sequence logos for the TF binding motif of BATF has been computed from putative BSs predicted by PMMs.