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. 2019 Feb 25;9:2638. doi: 10.1038/s41598-019-38788-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of non-CDR loops of interest. The analysis includes linking regions between the variable and constant domain (VC)⁴⁶ and the previously described AB-linker⁴⁷ and H3 region⁴⁸. (A) Radius of gyration of the AB-loop, (B) SASA of the AB-loop, (C) Radius of gyration of the VCalinker, (D) SASA of the VCa-linker, (E) Radius of gyration of the VCb-linker, (F) SASA of the VCb-linker, (G) Radius of gyration of the H3 region, (H) SASA of the H3 region.