Fig. 5.

Oxytocin transport after transient brain ischaemia. a Transient brain ischaemia was induced by 15 min of bilateral common carotid arteries occlusion (BCCAO) as described in Methods. RAGE and CD31 expression in vascular cells of the hippocampus were assessed 24 h after ischaemic insults; nuclei are stained with DAPI (Bar = 100 μm). b Quantitation of RAGE induction in CD31-positive endothelial cells (n = 5). c Fluorescein dye was used to check nonspecific vascular leakage and BBB damage following BCCAO (n = 3–6). ns, not significant. d Oxytocin concentrations in CSF from the cisterna magna of BCCAO or sham-operated WT (RAGE^+/+) or Ager^−/− male mice (n = 4–9). Values are mean ± SEM