Fig. 4.

Effective microRNAs (miRNAs) and genes used in risk prediction model. a The number of miRNAs used for final risk prediction models were 78, 86 and 110 in AD, VaD and DLB, respectively. The pie-chart showed the common and disease-specific miRNAs among these three diseases. b Using microRNA Target Prediction and Functional Study Database (miRDB), which can predict miRNA functional target genes, the 78 miRNAs in AD were predicted to target 1755 genes. The 86 miRNAs in VaD and 110 miRNAs in DLB were predicted to target 2017 and 2521 genes, respectively. The pie-chart showed the common and disease-specific target genes among these three diseases. AD Alzheimer’s disease, VaD vascular dementia, DLB dementia with Lewy bodies