Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 25;9:2676. doi: 10.1038/s41598-019-39276-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Representative A(H3N2) viruses utilized to generate HINT reference material. (A) HA1 sequences of human respiratory specimens selected to produce reference material (shown in bold) and cell-grown counterparts of viruses recommended as A(H3N2) vaccine strains during 2012–2017 (shown in grey). A/Victoria/361/2011 (M1: EPI ISL 101506), A/Texas/50/2012 (M1,C1: EPI ISL 101506), A/Switzerland/9715293/2013 (S1: EPI ISL 162149), A/Hong Kong/4801/2014 (S1: EPI ISL 165554); A/Singapore/INFIMH-16-0019/2016 (original: EPI ISL 225834) was recommended for the SH 2018 season. All viruses listed share sequons of N-glycosylation at residues 8, 22, 38, 45, 63, 165, 246, 246, 285 in HA1 and 154 in HA2. AA 128 belong to antigenic site B, however substitution T128N/A results in loss of glycosylation on N126 (antigenic site A). RBS: Receptor binding site. (B) Phylogenetic relationship among representative influenza A(H3N2) HA genes. Clinical specimens used in this study are underlined, and vaccines are marked with an asterisk. Branching patterns are color-coded by A(H3N2) HA genetic clade. Bootstraps per parent node and the scale bar (in nucleotide mutations per site) are indicated.