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. 2019 Feb 25;10:931. doi: 10.1038/s41467-019-08862-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A speculative model for the role of Cep57 in centriole engagement and PCM integrity during mitosis. Cep57 localizes at the proximal ends of mother centrioles and directly binds to the PACT domain of PCNT. The binding of PCNT to Cep57 at centrioles is required for the proper localization pattern of PCNT to organize the highly ordered PCM structure and to maintain the centriole engagement during mitosis. In the absence of Cep57, the PCNT height that binds along the side of centriole wall is affected, which causes PCNT dispersion and PCM disorganization. PCM disorganization further leads to precocious centriole disengagement during mitosis. Precociously disengaged daughter centrioles aberrantly recruit PCM components and acquire ectopic MTOC activity, which thereby causes chromosome segregation errors and aneuploidy