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. 2019 Feb 25;9:2711. doi: 10.1038/s41598-019-39077-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Medium conditioned by EPC limits acinar differentiation. (a) RT-qPCR analysis of acinar markers Cpa and Amy reported to β-actin in explants cultured for 2 and 3 days in the presence of control medium (Ctrl), endothelial cells (+EPC) or of medium conditioned by EPC (+CM). Both EPC and CM limit acinar differentiation. (Mann-Whitney for control explants: °°p < 0.01; °°°p < 0.001; and for EPC- and CM-treated explants: **p < 0.01; ***p < 0.001). (b) Immunofluorescence for Amylase (green) within the pancreatic epithelium (E-Cadherin, red) of control explants (Ctrl) or of explants treated with conditioned medium (+CM) at 2 and 3 days. Fewer Amylase⁺ cells are observed following culture with CM.