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. 2019 Feb 25;9:2711. doi: 10.1038/s41598-019-39077-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EPC-CM treatment induces the expression of Carbonic Anhydrase 2 (Car2). RT-qPCR analysis of progenitor, endocrine and ductal markers reported to β-actin in pancreatic explants cultured for 3 days in control medium (Ctrl), EPC-CM (+CM) and in the presence of laminin-α1β1γ1 (+Lamα1β1γ1). EPC-CM and laminin-α1β1γ1 do not affect expression of progenitor (Prox1) and endocrine (Ins2 and Gcg) markers. Conversely, the treatments upregulate the expression of the ductal marker Car2, although the expression of the ductal transcription factors Sox9 and Hnf1β remain stable. (Mann-Whitney: ***p < 0.001).