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. 2019 Feb 25;10:928. doi: 10.1038/s41467-019-08841-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — RNA-seq analysis of cortical GABA interneurons derived from hESCs with different FOXG1 dosage. a MA plots chart of differentially expressed genes (DEGs) compared to FOXG1 (ASV = 0) group. Red, blue and gray dots represent up-regulated, down-regulated DEGs and non-DEGs. b DEGs between each ASV treated and the untreated FOXG1 (ASV = 0) group. c Correlation heatmap showing weaker correlation between FOXG1 discriminated groups. d Expression profile presenting of two different clusters of DEGs. Left shows dose-dependent regulation by FOXG1, while right shows binary regulation by FOXG1. Coloring indicates the log2 transformed fold change. e Expression profile of key genes related to GABA neuron development and GABAergic synapses formation. Coloring indicates the log2 transformed fold change