Table III.

Top 5 up- and downregulated mRNAs associated with lung cancer.

Author, year	Genesymbol	FC(abs)	Regulation	Reported function in lung cancer	(Refs.)
Pan et al, 2016	TTR	6.91	Up	Reduced transthyretin expression in sera of lung cancer	(21)
Liu et al, 2007	SLC5A10	5.21	Up	DNA methylation in SLC5A8 expression in lung cancer cell lines, Reduced or lost expression of SLC5A8 was observed in tumor tissues	(50)
Park et al, 2013 and Tsai et al, 2014	RAB37	4.73	Up	Lung cancer patients with metastasis and poor survival show low hRAB37 protein expression	(51)
				Knockdown of hRAB37 in low metastasis cell line led to a significant increase in cell migration	(52)
Wu et al, 2009	ITIH5	3.46	Up	ITIH5 mRNA expression was significantly decreased in NSCLC compared to normal lung tissue, ITIH5 may be a novel putative tumor suppressor gene in NSCLC	(53)
Dötsch et al, 2015	IGFBP7	3.08	Up	(IGFBP7) was considered a tumor suppressor gene in lung cancer.	(54)
Chen et al, 2011	GREB1	5.58	Down	The expression of GREB1 in lung cancers is significantly higher than that in normal lung tissues, and closely related to smoking	(55)
Zhang et al, 2012 and McLemore et al, 1990	CYP1A1	10.22	Down	A biomarker for lung cancer risk, and closely related to smoking	(56,57)
Taioli et al, 1998	CLSPN	5.24	Down	Claspin contribute to the radioresistance of lung cancer brain metastases	(58)
Choi et al, 2014 and Taniguchi et al, 2016	AREG	4.72	Down	AREG can cause lung tumorigenesis and resistance to crizotinib	(59,60)
Taron et al, 2004	BRCA1	3.08	Down	BRCA1 as an indicator of chemoresistance in lung cancer	(61)

abs, absolute; AREG, amphiregulin; BRCA1, breast cancer 1; CLSPN, claspin; CYP1A1, cytochrome P450 family 1 subfamily A member 1; FC, fold-change; IGFBP7, insulin like growth factor binding protein 7; ITIH5, inter-α-trypsin inhibitor heavy chain family member 5; SLC5A10, solute carrier family 5 member 10; TTR, transthyretin.