Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 21;19(3):1654–1664. doi: 10.3892/mmr.2018.9785

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 6. — Roles of mitochondrial, mitogen-activated kinase and STAT3 signaling pathways in the apoptosis of EPDMNQ- and ENDMNQ-treated Hep3B cells. Detection of p-ERK, p-JNK, p-p38, p-STAT3, Bax, Bcl-2, cle-PARP and cle-caspase-3 protein expression in (A) EPDMNQ- and (B) ENDMNQ-treated Hep3B cells by western blot analysis. ***P<0.001 vs. untreated control groupl. EPDMNQ, 2,3-dihydro-2,3-epoxy-2-propylsulfonyl-5,8-dimethoxy-1,4-naphthoquinone; ENDMNQ, 2,3-dihydro-2,3-epoxy-2-nonylsulfonyl-5,8-dimethoxy-1,4-naphthoquinone; Bcl-2, B-cell lymphoma 2; Bax, Bcl-2-associated X protein; cle, cleaved; PARP, poly (adenosine 5-diphosphate-ribose) polymerase; p, phosphorylated; p38, p38 mitogen-activated protein kinase; JNK, c-Jun N-terminal kinase; ERK, extracellular signal regulated kinase; STAT3, signal transducer and activator of transcription 3.