Table IV.
KEGG pathways of weighted gene co-expression network analysis modules.
| Module name | KEGG pathways | Input number | P-value |
|---|---|---|---|
| Black module | hsa04080:Neuroactive ligand-receptor interaction | 13 | 1.02×10−8 |
| hsa01100:Metabolic pathways | 21 | 3.37×10−7 | |
| hsa04020:Calcium signaling pathway | 8 | 7.78×10−6 | |
| hsa04810:Regulation of actin cytoskeleton | 7 | 1.05×10−5 | |
| hsa00830:Renin secretion | 4 | 2.61×10−5 | |
| hsa05202:Transcriptional misregulation in cancer | 6 | 2.84×10−5 | |
| hsa04110:Cell cycle | 5 | 7.34×10−5 | |
| hsa04151:PI3K-Akt signaling pathway | 8 | 1.23×10−4 | |
| hsa05200:Pathways in cancer | 8 | 2.45×10−4 | |
| hsa04014:Ras signaling pathway | 5 | 5.83×10−4 | |
| hsa04022:cGMP-PKG signaling pathway | 6 | 6.04×10−4 | |
| hsa04024:cAMP signaling pathway | 5 | 6.50×10−4 | |
| hsa04010:MAPK signaling pathway | 6 | 7.21×10−4 | |
| hsa05219:Bladder cancer | 4 | 7.37×10−4 | |
| hsa05218:Melanoma | 4 | 7.59×10−4 | |
| hsa04068:FoxO signaling pathway | 3 | 7.66×10−4 | |
| hsa04510:Focal adhesion | 5 | 8.40×10−3 | |
| hsa04923:Regulation of lipolysis in adipocytes | 4 | 4.38×10−3 | |
| hsa05160:Hepatitis C | 4 | 1.20×10−2 | |
| hsa04072:Phospholipase D signaling pathway | 3 | 3.34×10−2 | |
| hsa04144:Endocytosis | 4 | 4.93×10−2 | |
| Blue module | hsa01100:Metabolic pathways | 15 | 3.10×10−3 |
| hsa04020:Calcium signaling pathway | 5 | 3.17×10−3 | |
| hsa04080:Neuroactive ligand-receptor interaction | 6 | 4.24×10−3 | |
| hsa04060:Cytokine-cytokine receptor interaction | 8 | 3.67×10−2 | |
| hsa04080:Neuroactive ligand-receptor interaction | 6 | 3.69×10−2 | |
| hsa04068:FoxO signaling pathway | 3 | 4.02×10−2 | |
| hsa04922:Glucagon signaling pathway | 3 | 4.53×10−2 | |
| Magenta module | hsa04530:Tight junction | 6 | 3.27×10−6 |
| hsa04514:Cell adhesion molecule | 4 | 8.15×10−4 | |
| hsa05219:Bladder cancer | 3 | 6.33×10−3 | |
| hsa04390:Hippo signaling pathway | 3 | 9.48×10−3 | |
| hsa05218:Melanoma | 2 | 9.51×10−3 | |
| hsa05100:Bacterial invasion of epithelial cells | 3 | 1.75×10−2 | |
| hsa05200:Pathways in cancer | 4 | 1.88×10−2 | |
| hsa04670:Leukocyte transendothelial migration | 3 | 2.07×10−2 | |
| Red module | hsa04110:Cell cycle | 11 | 3.77×10−11 |
| hsa04114:Oocyte meiosis | 10 | 6.60×10−1° | |
| hsa04914:Progesterone-mediated oocyte maturation | 7 | 5.89×10−7 | |
| hsa04115:p53 signaling pathway | 4 | 3.63×10−4 | |
| hsa05200:Pathways in cancer | 6 | 7.66×10−4 | |
| hsa01100:Metabolic pathways | 12 | 2.08×10−3 | |
| hsa04152:AMPK signaling pathway | 3 | 4.54×10−3 | |
| hsa05166:HTLV-I infection | 4 | 7.30×10−3 | |
| hsa04060:Cytokine-cytokine receptor interaction | 4 | 1.10×10−2 | |
| hsa04080:Neuroactive ligand-receptor interaction | 4 | 1.33×10−2 | |
| hsa00982:Drug metabolism-cytochrome P450 | 2 | 1.36×10−2 | |
| hsa00980:Metabolism of xenobiotics by cytochrome P450 | 2 | 2.13×10−2 | |
| hsa01524:Platinum drug resistance | 2 | 2.13×10−2 | |
| hsa01230:Biosynthesis of amino acids | 2 | 3.38×10−2 | |
| hsa00430:Taurine and hypotaurine metabolism | 2 | 4.54×10−2 | |
| hsa05203:Viral carcinogenesis | 3 | 4.83×10−2 | |
| Turquoise module | hsa04110:Cell cycle | 17 | 3.25×10−15 |
| hsa05166:HTLV-I infection | 12 | 4.94×10−6 | |
| hsa04114:Oocyte meiosis | 8 | 5.99×10−6 | |
| hsa05200:Pathways in cancer | 13 | 2.23×10−5 | |
| hsa05202:Transcriptional misregulation in cancer | 8 | 2.94×10−5 | |
| hsa04914:Progesterone-mediated oocyte maturation | 6 | 8.26×10−4 | |
| hsa01040:Biosynthesis of unsaturated fatty acids | 3 | 1.36×10−2 | |
| hsa01212:Fatty acid metabolism | 3 | 4.05×10−2 | |
| Yellow module | hsa04668:TNF signaling pathway | 12 | 4.98×10−13 |
| hsa04380:Osteoclast differentiation | 9 | 2.27×10−10 | |
| hsa05166:HTLV-I infection | 11 | 2.03×10−8 | |
| hsa05323:Rheumatoid arthritis | 7 | 5.60×10−8 | |
| hsa04933:AGE-RAGE signaling pathway in diabetic complications | 7 | 3.68×10−7 | |
| hsa04010:MAPK signaling pathway | 7 | 7.13×10−7 | |
| hsa04210:Apoptosis | 5 | 2.20×10−4 | |
| hsa05161:Hepatitis B | 5 | 5.67×10−4 | |
| hsa05142:Chagas disease (American trypanosomiasis) | 4 | 6.82×10−4 | |
| hsa04620:Toll-like receptor signaling pathway | 4 | 1.58×10−3 | |
| hsa05168:Herpes simplex infection | 5 | 1.69×10−3 | |
| hsa01100:Metabolic pathways | 14 | 1.93×10−2 | |
| hsa04510:Focal adhesion | 5 | 4.47×10−2 |
KEGG, Kyoto Encyclopedia of Genes and Genomes; PI3K, phosphoinositide 3-kinase; Akt, protein kinase B; cGMP, cyclic guanosine monophosphate; PKG, protein kinase G; cAMP, adenosine monophosphate; MAPK, mitogen-activated protein kinase; AMPK, 5′ AMP-activated protein kinase; HTLV-1, human T-cell leukemia virus type 1; TNF, tumor necrosis factor; AGE, advanced glycation endproducts; RAGE, receptor for advanced glycation endproducts.