Table IV.
Comparisons of genotype and allele frequency distribution in rs2119882 of MTNR1A and rs10830963 of MTNR1B between the NOB-PCOS group and the OB-PCOS group.
| SNP | NOB-PCOS group (n=191) | OB-PCOS group (n=168) | P-value | OR (95% CI) |
|---|---|---|---|---|
| rs2119882 | ||||
| TT | 40 (20.94) | 28 (16.67) | Ref | |
| TC | 96 (50.26) | 69 (41.07) | 0.928 | 1.027 (0.579–1.822) |
| CC | 55 (28.80) | 71 (42.26) | 0.044a,b | 1.844 (1.014–3.353) |
| TC + CC | 151 (79.06) | 140 (83.33) | 0.302 | 1.325 (0.776–2.262) |
| T | 176 (46.07) | 125 (37.20) | Ref | |
| C | 206 (53.93) | 211 (62.80) | 0.016a,b | 1.442 (1.069–1.945) |
| rs10830963 | ||||
| CC | 73 (38.22) | 52 (30.95) | Ref | |
| CG | 87 (45.55) | 82 (48.81) | 0.239 | 1.323 (0.829–2.110) |
| GG | 31 (16.23) | 34 (20.24) | 0.159 | 1.540 (0.843–2.814) |
| CG + GG | 118 (61.78) | 116 (69.05) | 0.149 | 1.380 (0.890–2.140) |
| C | 233 (60.99) | 186 (55.36) | Ref | |
| G | 149 (39.01) | 150 (44.64) | 0.126 | 1.261 (0.937–1.698) |
PCOS, polycystic ovary syndrome; NOB, non-obesity; OB, obesity; SNP, single nucleotide polymorphisms; OR, odds ratio; 95% CI, 95% confidence intervals; Ref, reference.
a
P<0.05 vs. PCOS and control groups
b
P<0.05 vs. OB-PCOS and control groups; Chi-square test was performed for enumeration data.