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. 2018 Dec 21;19(3):1543–1550. doi: 10.3892/mmr.2018.9787

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — miR-219 inhibits the expression of pro-fibrotic markers and the fibrosis level in a chronic mouse liver injury model. The miRNA-219 agonist was delivered by tail vein injection in the model mice. The mRNA expression of (A) collagen type I and (B) collagen type III was downregulated in liver tissue following miR-219 treatment. (C) H&E and Masson staining of liver tissues in mice. One-way analysis of variance was used in A and B. **P<0.01 vs. sham. miR, microRNA; H&E, hematoxylin and eosin (scale bar, 25 µm).