Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 19;9:31. doi: 10.3389/fcimb.2019.00031

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Ebensen, Delandre, Prochnow, Guzmán and Schulze.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Systemic humoral immune responses induced in mice after three immunizations with β-Gal co-administered with the adjuvant system c-di-AMP/alum via intramuscular route. (A) β-Gal–specific IgG titers in sera 13 days after the last immunization. (B) β-Gal–specific IgG1 and IgG2a in the sera of immunized mice (n = 10). Results are displayed as average of the last sera dilution (end point dilution, e.p.d) showing the double value (OD 405 nm) of the control background. Each bullet symbol indicates a single animal, whereas horizontal lines represent the mean of animals. (C) β-Gal–specific IgG1/IgG2a ratio in the sera of immunized mice. Statistically significant differences were validated using the one-way ANOVA with Tukey's post hoc test with p < 0.001 (***) and p < 0.0001 (****) when compared with β-Gal alone (*), or in combination with alum (o) or c-di-AMP (+), respectively.