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Schematic diagram of TF isoform expression. flTF consists of an intracellular domain, a transmembrane domain and an extracellular domain. asTF lacks the transmembrane domain and is therefore soluble. Retention of a part of intron 1 as alternative exon 1A in the mature transcript leads to the generation of the third variant, TF-A. asTF, alternatively spliced TF; flTF, full-length TF; TF, tissue factor.
