Skip to main content
. 2018 Dec 17;19(3):1463–1470. doi: 10.3892/mmr.2018.9773

Figure 3.

Figure 3.

MiR-495 inhibits the proliferation of A549 cells in a HMGA2-dependant manner. (A) Reverse transcription-quantitative polymerase chain reaction was used to determine the expression levels of miR-495 following transfection. The expression of miR-495 in the miR-495 mimics and miR-495 mimics + HMGA2 groups was significantly upregulated compared with in the mimic-NC group. ***P<0.001 vs. mimic-NC. (B-D) Expression of HMGA2 in A549 cells in the miR-495 mimics group was significantly downregulated compared with in the mimic-NC group. The protein expression levels of HMGA2 in the miR-495 mimics + HMGA2 groups were significantly upregulated compared with those in miR-495 mimics group. ###P<0.001 vs. miR-495 mimics; ***P<0.001 vs. mimic-NC. (E) Cell proliferation was evaluated by a Cell Counting Kit-8 assay. MiR-495 inhibited the proliferation of A549 cells, whereas HMGA2 overexpression could reverse this inhibition. **P<0.01. MiR, microRNA; HMGA2, high mobility group A2; NC, negative control.