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. 2019 Feb 25;9:2718. doi: 10.1038/s41598-019-39089-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Repeated ACTH administration experiment (described in McCormley et al.¹²) and blubber tissue sampling design. ACTH was administered to juvenile elephant seals once every 24 hours for 4 days. Blubber biopsies were collected immediately before ACTH administration (“pre-ACTH”) and 4 hours after ACTH administration (“ACTH response”) on the first and fourth days. RNA isolated from blubber tissue was used for transcriptome sequencing. Seal (color modified, from https://pixabay.com), syringe (from https://pixabay.com), adipose (enhanced contrast, from https://openclipart.org), and microcentrifuge tube (from http://www.clker.com) images were obtained under CC0 1.0 Universal: CC0 1.0 Public Domain Dedication. License: https://creativecommons.org/publicdomain/zero/1.0.