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. 2019 Feb 25;9:2678. doi: 10.1038/s41598-019-39591-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Scatter plot of mean cytoplasmic RNA-Seq read counts per gene, as normalised by DESeq2, comparing K700E cells to wildtype cells (n = 2). Axes plotted as biexponential (red = FDR < 0.05 FC > 2, blue = FDR < 0.05 & FC < −2). (B) Network of directly interacting proteins based on the set of genes identified as depleted in the cytoplasmic fraction of mutant cells (FDR0.05 FC < −1.5). Transcripts identified as having altered splicing in mutant cells are indicated as diamonds. Genes belonging to tRNA synthesis pathway (KEGG hsa00970) are labelled in red. Nodes coloured according to cluster assigned by Reactome FI. Protein-protein interactions identified by STRING-DB. Table lists top three enriched pathways for highlighted gene clusters and their FDR-adjusted p-values. (C) Plot of –log₁₀(FDR-adjusted p-value) against log₂(fold-change) for cytoplasmic RNAs WT vs SF3B1^K700E –only log2(fold-change) ±1.5 shown (n = 2). Genes from tRNA synthetase pathway (KEGG hsa00970) plotted as green triangles. Significantly differentially-expressed tRNA synthetases are labelled.